Dr. Subhendu Ghosh Lab
About the Lab and Research
Computational and Mathematical Modeling of Memory and Plasticity.
We are developing computational and mathematical models for both synaptic and intrinsic plasticity. These models are based on Hodgkin–Huxley, and FitzHugh–Nagumo models of the action potential. In particular, our interest is the threshold of action potential and the role of noise. In recent studies, it is observed that other than synaptic plasticity, neurons can modulate their own excitability, which plays a crucial role in information encoding and learning. This aspect of neuronal plasticity is being addressed through our mathematical model.
Role of Mitochondrial Ion Channels in Neuron’s Life and Death.
We are studying the role of ion channels like Voltage-Dependent Anion Channel (VDAC) and various kinases, e.g. PKA, MAP Kinase, CaM Kinase, in mitochondia mediated apoptosis. We are combining biophysical and electrophysiologica studies to investigate the structure-function relationship of VDAC with various pro-apoptotic agents and other ligands e.g. phytochemical compounds, plasminogen, Bif-1 etc
Gap Junction as Electrical Synapse
We are looking into the role of connexins (Electrical Synapse) in synaptic plasticity using electrophysiological, e.g. bilayer and patch-clamp, and spectroscopic methods, especially biochemical modifications and multichannel behavior.
Studies on Synthetic ion Channels.
We are interested in understanding the structure-function relationship of ion channels. In particular we are investigating the role of different domains of KvAP channel. KvAP is a potassium channel consisting of six trans-membrane domains. S6 is one of the pore domains assisting the transfer of potassium ions. We found S6 peptide itself can oligomerize on lipid membrane to form ion channel. In addition, we are looking into the potential of other synthetic compounds, e.g. crown ether, to form ion channel.
Noise in Biological System
Biomolecules in a cell exist in a dynamical state, hence associated with intrinsic noise. We are studying the intrinsic noise of bilayer membrane (BLM) and ion channels. BLM experimental data are being analyzed to characterize various noise patterns, which help us in understanding the dynamics of the system, especially the existence of Self Organized Criticality (SOC).
Collective Phenomena in Ion Channels
Collective phenomena have been observed in nature at various levels of the organization. The phenomena lead to the generation of exceptional properties of the system, which are otherwise not observable. The presence of ion channel clusters has been observed in various kinds of channels like Na, K, Ca Channels, VDAC, connexins, etc. The collective behavior of the ion channels is being studied using Statistical Mechanical Models, e.g. ising Model, combined with multichannel experimental data.
Systems Biology of Memory formation
It is known that Long Term Potential (LTP), a prelude to memory formation, takes place through a complex metabolic network in a neuron. Presently we are investigating the role of Calcium flux in pre and postsynaptic neurons through a systems biology approach using non-linear differential equations.
|T. Daniel Tuikhang Koren
SRF UGC PhD Scholar
Research Area: Biophysical Studies on Neuronal BK Channel.
|Shumaila Iqbal Siddiqui
SRF ICMR PhD Scholar
Research Area: Role of Ion Channels in Neurodegeneration
SRF DST-INSPIRE PhD Scholar
Research Area: Computational Modelling of Neuronal Plasticity
JRF CSIR PhD Scholar
Research Area: Theoretical Neuroscience
|Dr. Rajan Shrivastava UDSC , New Delhi||Dr. Kumud Kumar Singh
,(NIAID, NIH, US)
|Dr. B.R Pattnaik ( Prof. Uni. of Wisconsin, Madison)||Dr. Jyotirmoy Banerjee
(Asst. Professor, AIIMS, New Delhi)
|Dr. Smarajit Manna (Student Advisor JBNSTS, Kolkata)||Dr. Amal Kanti Bera
(Professor, IIT-M, Chennai))
|Dr. Paramita Ghosh (Associate Professor, Motilal Nehru College, University of Delhi, Delhi)||Dr. Viksita Vijayvergiya
(Postdoctoral Fellow, University of California Los Angeles, Los Angeles)
|Dr. M. Elizabeth Sobhia (Associate Professor, NIPER, Mohali)||Dr. Debashish Bose
(Assistant Professor Calcutta University)
|Dr. Pijush Kanti Jana (Head, Analytical Research Group - 1, Mylan Laboratories limited, Bollaram)||Dr. Archana Chaturvedi
(Assistant Professor, Department of Biochemistry, Amity University, Noida)
|Dr. Anindita Bhattacharjee (Assistant Professor, Department of Mathematics, Amity University, Noida)||Dr. Chetan Kumar Yadav
(Research Associate-3, National Brain Research Centre, Manesar, Haryana)
|Dr. Naveen Kumar Bhatraju (Research Associate, Institute of Genomics and Integrative Biology, Delhi)||Dr. Rajeev Gupta
(Postdoctoral Fellow, Department of Life Sciences, Ben-Gurion University, Israel)
|Dr. Chetan Malik (Visiting Scholar, Department of Biophysics, UDSC)||Dr. Prashant Chaturvedi